yego.me
💡 Stop wasting time. Read Youtube instead of watch. Download Chrome Extension

The Search for a Genetic Disease Cure | Explorer


2m read
·Nov 11, 2024

Iceland's Decode Laboratories is one of the world's leading genetic research facilities. Decode has been running large genomic studies now, in fact, for decades. They really did pioneer the standard approach, where what you do is enroll individuals into studies and make use of their existing clinical records for genomic discovery. This is now really the right way to do genomic studies.

Led by founder Kari Stefansson, Decode has been steadily collecting Icelandic DNA. To date, they've run a must a hundred and fifty thousand samples. So we've got half the population to give samples. However, you actually got some examples. We have made some systematic efforts now undone, but mostly this has been trickling in over 20 years. It's amazing to see all these samples in one place; each one is essentially the fundamental blueprint of an individual Icelander.

This is the concentrated DNA of a person, and it looks like a little bit approached. I mean, yes, in these little white pads that you see, there is enough information to make command. I mean, this is the sort of seek—the secrets of life are held within this.

But Decode isn't simply interested in archiving Icelandic DNA. They want to provide insights for curing genetic diseases. If you remember, many Icelanders are related, and in fact, their DNA is incredibly similar. It’s this similarity that Decode is harnessing. A population like Iceland, which is relatively more homogeneous, or that started from a modest number of founders and then grew, will make it easier to discover the role of certain genes.

Because you don't have to sequence absolutely everybody to uncover most of the genetic information. So this allows you to look for the genes which might be associated with particular diseases. Yes, because you don't have this background noise. You know, there isn't a background noise—it's less. But we are not only looking for the raw genes; we're looking for genes that protect against disease.

More Articles

View All
Estimating when subtracting large numbers
Let’s say that you have a jar of jelly beans, and you know that there are exactly 282 jelly beans in that jar of jelly beans. Then, the next day you come, and you see there are fewer. You say, “What happened?” Let’s say someone who lives with you or your …
Basic derivative rules: find the error | Derivative rules | AP Calculus AB | Khan Academy
So we have two examples here of someone trying to find the derivative of an expression. On the left-hand side, it says Avery tried to find the derivative of 7 - 5x using basic differentiation rules; here is her work. On the right-hand side, it says Hann…
BONUS: "FANBOYS," a mnemonic song | Conjunctions | Parts of speech| Khan Academy
Fanboy, Fanboy, the boys who carry the fan. Fanbo, Fanboy, the boys who had a plan. For the way was long and the day was hot. The boys were always prepared; neither sand nor heat would deter their feet. They did what no others had dared. Bo fanbo, th…
Stop Hiding Who You Really Are | The Philosophy of Friedrich Nietzsche
Your growth in life depends on how you spend your energy, and the best way to spend your energy is on solving the right problems. But which problems are the right ones to solve? I can’t stress how important, how critical, this question is. How do you kno…
Vitalik: Ethereum, Part 1
All right, welcome everybody back to the podcast. We have with us Haseeb Qureshi, who’s our partner at Dragonfly. Haseeb and I used to work together back when I was more active in crypto land. Vitalik is, of course, a polymath ingenue, although he may bri…
Expected payoff example: lottery ticket | Probability & combinatorics | Khan Academy
We’re told a pick four lottery game involves drawing four numbered balls from separate bins, each containing balls labeled from zero to nine. So, there are ten thousand possible selections in total. For example, you could get a zero, a zero, a zero, and a…